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Ahvaz Jundishapur University of Medical Sciences

Study the effects of malva sylvestris hydro-alcoholic extract onThecarrageenan-induced inflammation in male rat paw

ارضی, اردشیر and نظري خوراسگانی, زهرا and رحمانی, محمد (2013) Study the effects of malva sylvestris hydro-alcoholic extract onThecarrageenan-induced inflammation in male rat paw. JENTASHAPIR JOURNAL OF HEALTH RESEARCH, 4.

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Abstract

Background: Using chemical drugs have often masses of damaged side effects Therefore,it is important to research about medicinal plants with anti-inflammation and fewer side effects.malvasylvestris has potential use as a medicinal plant. The aim of this study was to investigate the effect of Malva Sylvestris flowers hydroalcoholic extract on the carrageennan-induced inflammatory response using Wistar male rats' paws. Material and methods: Malva Sylvestris flowers powder wasmacerated with 70%ethanol, and its extract prepared. Male Wistar rats were divided into 6 groups of 10 animals each for following treatments: Malva extract (200,400,600 and 800 mg/kg), normal saline (5mg/kg) as negative control and Aspirin (300mg/kg) as a positive via IP.Thirty min later inflammation was induced by injection of 100µlcarrageenan (1%W/V) into the rat's hind paw of rats(SC). The inflamation response changes were inspected over 5 hours every hour, using plethysmometer.. Results: The extract-treated (600,800 mg/kg) showed considerable reduction in the rats' paws inflamation when compared with control groop(p>0.05). But 200 and 400 mg/kg extract showed no considerable decrease in inflamation when comparied with control group (p<0.05). There was not significant differences between doses of 600 and 800 mg/kg of extract, therfore dose of 600 mg/kg was selected as the most favorable dose as anti-inflamation

Item Type: Article
Keywords: واژگان کلیدي: گل پنيرک، آسپيرين، كاراژينان، التهاب، موش صحرايي.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 06 Feb 2018 06:09
Last Modified: 06 Feb 2018 06:09
URI: http://eprints.ajums.ac.ir/id/eprint/11738

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