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Ahvaz Jundishapur University of Medical Sciences

Epstein-Barr Virus DNA frequency in paraffin embedded tissues of Non-Hodgkin lymphoma patients from Ahvaz, Iran

Habibian, Ala and Makvandi, Manoochehr and Samarbafzadeh, Alireza and Neisi, Niloofar and Ranjbari, Nastaran (2013) Epstein-Barr Virus DNA frequency in paraffin embedded tissues of Non-Hodgkin lymphoma patients from Ahvaz, Iran. Jentashapir Journal of Health Research, 4 (4).

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Abstract

Background: Epstein-Barr Virus (EBV) is a DNA virus which belongs to the Herpesviridae family and in γ-herpesvirus subfamily, has been infected about 95% of the world’s population. EBV is transmitted through saliva and associated with different disease such as Infectious Mononucleosis, Nasopharyngeal Carcinoma, Burkitt`s lymphoma, Hodgkin and Non-Hodgkin`s lymphoma.. The study proposed to determine the frequency of Epstein-Barr Virus expression in histological tissue of Non-Hodgkin's lymphoma in Ahvaz, Iran.. Material and methods: In this study 29 samples of Non-Hodgkin`s lymphoma were examined from Ahvaz Imam Khomeini Hospital, using Nested-PCR technique on EBNA-1 region in order to determine the presence of EBV genome in tumoral tissues. . Results: Among 29 cases of Non-Hodgkin's lymphoma, 14 (48%) cases were positive for EBV. Out of 14 samples of Non-Hodgkin`s lymphoma, 4(28.57%) were female and 10 (71.42%) were male. A number of 8 (57%) cases belonged to the adults age group which proves association between age and EBV positive Non-Hodgkin`s lymphoma according to Fisher`s exact test (P=0.03). However, in the current study there was no significant difference between EBV positive cases and sex subject (P=0.626). .

Item Type: Article
Keywords: Non-Hodgkin`s lymphoma, Epstein-Barr Virus, Nested-PCR
Subjects: Q Science > QR Microbiology
Q Science > QR Microbiology > QR355 Virology
R Medicine > RZ Other systems of medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 07 Feb 2018 04:32
Last Modified: 07 Feb 2018 04:32
URI: http://eprints.ajums.ac.ir/id/eprint/11787

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