Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

Protective Effects of Zinc Supplementation on Renal Toxicity in Rats Exposed to Cadmium

Morshedi, Raziyeh and Ahmadizadeh, Massumeh and Ahmadi Angali, Kambiz (2014) Protective Effects of Zinc Supplementation on Renal Toxicity in Rats Exposed to Cadmium. Jundishapur Journal of Health Sciences. ISSN 2252-0627


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Background: Cadmium (Cd) is a nonessential element with many industrial applications and is one of the most toxic pollutants in the environment. The ultimate goal of occupational health is prevention of health hazards on workplace; hence, is as a hazardous chemical contaminant in the workplace, Cd needs special attention. Objectives: The object of this study was to determine the effect of ZnCl2 on Cd-induced nephrotoxicity in rats. Materials and Methods: Adult male rats were given CdCl2 at doses of 0, 1, 2, and 3 mg/kg. Another series of rats were pretreated with 4 mg/kg of ZnCl2 30 minutes prior to administration of various doses of CdCl2. The experiment was repeated for seven consecutive days. Twenty-four hours after administering the latest dose, animals were sacrificed. Blood samples were analyzed for blood urea nitrogen (BUN) and creatinine levels. Kidney tissues were excised for measuring malondialdehyde (MDA) concentration. Results: In contrast to the animals that received ZnCl2, CdCl2 induced a dose-dependent elevation in BUN, creatinine, and MDA in those without ZnCl2 pretreatment. Zinc chloride had significantly decreased all biochemical parameters and protected kidney cells against Cd-induced toxicity. Conclusions: The results of this study supported the potential protective effects of ZnCl2 on rat kidney tissues against CdCl2 toxicity.

Item Type: Article
Keywords: Keywords: Zinc Chloride; Cadmium Chloride; Malondialdehyde; Kidney; Rat
Subjects: Q Science > QP Physiology
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 05 Mar 2018 08:32
Last Modified: 05 Mar 2018 08:32

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