Repository of Research and Investigative Information

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Ahvaz Jundishapur University of Medical Sciences

The preventive effect of vitamin E on cadmium chloride-induced toxicity in rat liver and kidney

Ahmadizadeh, Masoomeh and Baghpa, Abdolrahman (2007) The preventive effect of vitamin E on cadmium chloride-induced toxicity in rat liver and kidney. Jundishapur Scientific Medical Journal, 6 (4).

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Abstract

Objective: Environmental exposure to cadmium (Cd) occurs via food, occupational industries, terrestrial and aquatic ecosystem. Increasing evidence indicated that Cd induced toxicity in human and animals. However, The mechanism by which its produced toxicity is not completely understood. It has been shown that lipid peroxidation is involved in Cd–related toxicity. Vitamin E is an effective antioxidant and free radical scavenger. The aim of this study is to investigate the preventive effect of vitamin E on cadmium-induced toxicity in rat liver and kidney. Materials and Methods:Adult NMARI male rats were treated with 5mg/kg vitamin E or corn oil (vehicle) only. 30 min later animals were given Cd Cl2 (ip) at doses of 0.5, 1, 1.5 and 2 mg/kg. The control group received normal saline (vehicle). All animals were treated for 7 consecutive days. 24 hr after last administration all rats were killed with over dose of sodium pentobarbital. The blood was collected for determinations of ALT, AST, ALP, BUN and creatinine. The liver and kidney tissues were removed, fixed and processed for light microscopy, using H&E staining method. CdCl2 induced dose-dependent injury in both liver and kidney tissues. Results: Statistical analysis showed significant increase all biochemical parameters in CdCl2-treated rats when compared to control groups (p>0.05). Vitamin E had no effect on rat liver or kidney. However, this agent protected cells against CdCl2 toxicity. Conclusion: The results of this study support the view that vitamin E has potential to protect rat liver and kidney tissues against CdCl2 toxicity.

Item Type: Article
Keywords: Cadmium chloride, Vitamin E, Liver, Kidney, Rat
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 26 Mar 2018 04:17
Last Modified: 26 Mar 2018 04:17
URI: http://eprints.ajums.ac.ir/id/eprint/12397

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