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Ahvaz Jundishapur University of Medical Sciences

Evaluation Immunohistochemical of BCL-2 Marker Expression in Pleomorphic Adenoma and Adenoid Cystic Carcinoma and Polymorphous Low Grade Adenocarcinoma

Assareh, Fatemeh and Gachkooban, Abdolmohammad and Dastani, Ahmad and Zare, Maryam (2015) Evaluation Immunohistochemical of BCL-2 Marker Expression in Pleomorphic Adenoma and Adenoid Cystic Carcinoma and Polymorphous Low Grade Adenocarcinoma. Jundishapur Scientific Medical Journal. ISSN 2252-0619

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Abstract

Abstract Background and Objective: BCL-2 is the first gene involved in apoptosis and was regarded as a proto-oncogene that suppresses the cell death rather than stimulating cell proliferation. The present study was conducted to assess and compare the immunohistochemical expression of BCL-2 in selected benign (Pleomorphic adenoma) (PA) and (adenoid cystic carcinoma and polymorphous low grade adenocarcinoma) (ACC, PLGA) salivary gland tumors. Materials and Methods: In this in vitro study seven ACC and three PLGA tumors were considered as malignant and 17 PA as benign tumors. The immunohistochemical staining procedure was performed using BCL-2marker, as directed by the manufacturer. Results were assessed in percentage of cells stained in 0-3 [0(negative), 1(1%-30%), 2(31%-70%), 3(71%-100%)] scores. Results: All malignant tumors showed a positive expression for BCL-2whereas only %58 of benign tumors was positive. Statistical significance was observed with regard to BCL-2expression in benign and malignant tumors. In findings of this study no relationship between BCL-2expression with independent variables such as age, sex, and the origin of the lesion was found. Conclusion: According the results of the present study greater expression of BCL-2in malignant salivary gland neoplasm suggests a higher survival rate of tumor cells in malignant tumors. It seems that BCL-2 is not a suitable marker to differentiate various salivary gland tumors from each other. ►Please cite this paper as: Asareh F, Gachkooban M, Dastani A, Zarei M. Evaluation Immunohistochemical of BCL-2 Marker Expression in Pleomorphic Adenoma and Adenoid Cystic Carcinoma and Polymorphous Low Grade Adenocarcinoma. Jundishapur Sci Med J; Suppl 2016: 9-19

Item Type: Article
Keywords: BCL-2, salivary gland tumor, Pleomorphic adenoma, immunohistochemical stain
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 05 May 2018 09:08
Last Modified: 13 Aug 2018 04:29
URI: http://eprints.ajums.ac.ir/id/eprint/13075

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