Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

Thyroid stimulating hormone and leptin levels and severe growth retardation among β- thalassemic patients

Dayer, D. and Salahcheh, M. and Mousavi Jazayeri, S. M. H. and Kaydani, G. A. and Kadkhodaei Elyaderani, M. and Shaneh, S. (2012) Thyroid stimulating hormone and leptin levels and severe growth retardation among β- thalassemic patients. Pakistan Journal of Medical Sciences, 28 (3). pp. 421-423. ISSN 1682024X (ISSN)

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Abstract

Objective: It has been proposed that Thyroid Stimulating Hormone (TSH) influences leptin secretion from adipocytes. We evaluated the association between TSH and leptin levels in thalassemic patients with growth retardation. Methodology: Blood samples were collected from 30 major thalassemic patients and 24 normal subjects (range: 12 - 20 y). Both Leptin and TSH were measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. The anthropometric data were collected based on standard methods. Independent sample t-test and Pearson's correlation were used to analyze data. Results: Patients had severe growth retardation. Mean concentration of leptin in thalassemic patients was significantly lower than normal subjects (2.26±2.61 vs 13.14±15.95 ng/ml). The mean value of serum TSH concentration in β- thalassemic patients was higher than normal subjects. But the difference was not statistically significant (P = 0.146). There was no marked relationships between TSH and leptin concentrations in thalassemic patients (r= -0.022, P = 0.909) and in control group (r=0.289, P=0.214).

Item Type: Article
Keywords: ß- Thalassemia Leptin TSH thyrotropin adolescent adult anthropometry article beta thalassemia blood sampling child clinical article controlled study disease association disease severity enzyme linked immunosorbent assay growth retardation hormone blood level hormone determination human leptin blood level reference value school child thyrotropin blood level
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences
Depositing User: مهندس مهدی شریفی
Last Modified: 01 Jun 2018 11:27
URI: http://eprints.ajums.ac.ir/id/eprint/14913

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