Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

Central nervous system niche involvement in the leukemia

Heidari, N. and Saki, N. and De Filippis, L. and Shahjahani, M. and Teimouri, A. and Ahmadzadeh, A. (2016) Central nervous system niche involvement in the leukemia. Clinical & Translational Oncology, 18 (3). pp. 240-250. ISSN 1699-048X

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Official URL: <Go to ISI>://WOS:000370184400002

Abstract

Central nervous system (CNS) impairment is commonly involved in leukemia, as it can be observed upon onset or relapse of the disease. It is associated with poor prognosis and is a challenging clinical problem. The objective of this paper was to provide a characterization of the CNS niche in leukemia, to elucidate the culprits of CNS involvement, including diagnostic micro RNAs (miRs) and early leukemia prognosis. CNS niche is a proper location for homing of leukemic stem cells, thus representing a candidate target in the treatment of leukemia. Recent advances in the study of leukemia hallmarks have enlightened miRs as novel biomarkers for diagnosis and detection of CNS involvement in leukemia, thus providing the opportunity to develop novel therapeutic approaches. Given the importance of prognosis and early diagnosis of CNS involvement in leukemias as well as the severe side effects of current treatments, diagnostic and therapeutic approaches should focus on identification and inhibition of the factors contributing to CNS involvement, including CXCR3, P-selectin glycoprotein ligand-1 and MCP1. MiRs such as miR-221 and miR-222 are emerging as potential tools for an innovative non-invasive therapy of CNS in leukemia affected patients.

Item Type: Article
Keywords: central nervous system stem cell niche leukemia chemokine microrna acute lymphoblastic-leukemia neural stem-cells acute myeloid-leukemia chronic lymphocytic-leukemia brain endothelial-cells cerebrospinal-fluid progenitor cells adult brain subventricular zone down-regulation
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences
Depositing User: مهندس مهدی شریفی
Last Modified: 01 Jun 2018 11:30
URI: http://eprints.ajums.ac.ir/id/eprint/15381

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