Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

Investigation on the effect of static magnetic field up to 30mT on viability percent, proliferation rate and IC50 of HeLa and fibroblast cells

Zafari, J. and Jouni, F. J. and Abdolmaleki, P. and Jalali, A. and Khodayar, M. J. (2015) Investigation on the effect of static magnetic field up to 30mT on viability percent, proliferation rate and IC50 of HeLa and fibroblast cells. Electromagnetic Biology and Medicine, 34 (3). pp. 216-220. ISSN 1536-8378

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Official URL: <Go to ISI>://WOS:000364542300008

Abstract

We have investigated the effects of static magnetic field (SMF) on the viability of the human cervical cancer (HeLa) cell line and fibroblast cells. The cells were cultured in DMEM medium and treated several times (24, 48,72 and 96h) and at several intensities (5, 10, 20 and 30mT) of magnetic field (MF). The cytotoxicity and cell viability percent in treated cells were performed using MTT assay by evaluating mitochondrial dehydrogenase activity. The MF ability on inducing cell death or inhibiting biochemical function was reported as cell death percent. The results showed that the increase of MF intensity and the time that cells were exposed to this treatment increased sharply cell death percent and proliferation rate in HeLa cell compare to fibroblast cells. Our data suggest that SMF biological effects on cell death were different in our selected targets. Cell type and time of exposure have been therefore found to be significant factors. These findings could be used to improve new effective method using SMF in conjunction with the common therapeutic approaches.

Item Type: Article
Keywords: fibroblast cells human cervical cancer (hela) cell line proliferation rate static magnetic field viability percent marrow stem-cells electromagnetic-fields natural radioactivity strand breaks vicia-faba apoptosis exposure cancer mt growth
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences
Depositing User: مهندس مهدی شریفی
Last Modified: 01 Jun 2018 11:31
URI: http://eprints.ajums.ac.ir/id/eprint/15737

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