Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

The effect of alpha-lipoic acid (ALA) supplementation on cardiovascular risk factors in men with chronic spinal cord injury: A clinical trial

Mohammadi, V. and Khalili, M. and Eghtesadi, S. and Dehghani, S. and Jazayeri, S. and Aghababaee, S. K. and Sabour, H. and Saberi, H. and Eghtesadi, M. and Gohari, M. R. (2015) The effect of alpha-lipoic acid (ALA) supplementation on cardiovascular risk factors in men with chronic spinal cord injury: A clinical trial. Spinal Cord, 53 (8). pp. 621-624. ISSN 13624393 (ISSN)

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Abstract

Study design:A randomized, double-blind, placebo-controlled clinical trial.Objective:To assess the effect of alpha-lipoic acid (ALA) supplementation on IL-6, hs-CRP, FBS, anthropometric indices, food intake and blood pressure in male patients with chronic spinal cord injury (SCI).Setting:Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.Methods:Fifty-eight men with chronic SCI participated in the study. Participants were divided in two groups: one group received 600 mg of supplemental ALA (n=28) and the other group received placebo (n=30) for 12 weeks. At the beginning and end of the study, biochemical parameters, anthropometric indices, blood pressure and dietary intakes were measured. Dietary intake was measured using N4 software, and statistical analyses were carried out using SPSS16.Results:No significant reduction was found in IL-6 (P=0.97) and hs-CRP levels (P=0.23). There was significant reduction in fasting blood sugar (P=0.001), body weight (P=0.001), BMI (P=0.001), waist circumference (P=0.001) and blood pressure (P=0.001). Dietary intake was significantly reduced, including fat (P=0.001), carbohydrate (P=0.001), protein (P=0.002) and energy intakes (P=0.001).Conclusion:Lipoic acid supplementation had no significant effect on the measured inflammatory markers but it reduces fasting blood sugar, anthropometric parameters, food intake and blood pressure in men with chronic SCI. © 2015 International Spinal Cord Society.

Item Type: Article
Keywords: C reactive protein interleukin 6 placebo thioctic acid glucose blood level vitamin B complex adult anthropometric parameters Article blood pressure caloric intake cardiovascular risk controlled study diet restriction diet supplementation dietary intake double blind procedure drug mechanism energy balance food intake human major clinical study male priority journal randomized controlled trial spinal cord injury waist circumference anthropometry blood blood analysis body mass Cardiovascular Diseases complication diet therapy eating Iran physiology risk factor Blood Chemical Analysis Blood Glucose Body Mass Index Double-Blind Method Fasting Humans Risk Factors Spinal Cord Injuries
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences
Depositing User: مهندس مهدی شریفی
Last Modified: 01 Jun 2018 11:31
URI: http://eprints.ajums.ac.ir/id/eprint/16294

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