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Ahvaz Jundishapur University of Medical Sciences

ANTIULCER ACTIVITY OF CRUDE ALCOHOLIC EXTRACTS OF BOUGAINVILLEA SPECTABILIS WILLD

Malairajan, P and Gopalakrishnan, G and Narasimhan, S and Kala Veni K, Jessi (2007) ANTIULCER ACTIVITY OF CRUDE ALCOHOLIC EXTRACTS OF BOUGAINVILLEA SPECTABILIS WILLD. Jundishapur Journal of Natural Pharmaceutical Products, 2 (1). pp. 1-6. ISSN 2228-7876

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Abstract

The ethanol extract of Bougainvillea spectabilis (ALBS) leaves were studied for its antiulcer activity against aspirin plus pylorus ligation induced gastric ulcer, HCl /ethanol induced ulcer and water immersion stress induced ulcer in rats. The results were compared with ranitidine, sucralfate, omeprazole respectively, for each model suggesting a mechanism for the pharmacological action (antisecretory, cytoprotection, proton pump hypothesis were evaluated). The ethanol extract of Bougainvillea spectabilis showed reduction in gastric volume, free acidity, total acidity and the ulcer inhibition was found to be 100%. The plant extract showed significant cytoprotective effect 89.71% and the extract showed protection index 72% in water immersion stress induced ulcer.

Item Type: Article
Keywords: Antiulcer, Bougainvillea spectabilis, Aspirin pyloric ligation ulceration, HCl/ethanol ulceration, Water immersion stress induced ulcer.
Subjects: R Medicine > R Medicine (General)
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 23 Jun 2015 12:15
Last Modified: 10 Feb 2016 06:50
URI: http://eprints.ajums.ac.ir/id/eprint/1669

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