Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

Stem cell therapy ‒Approach for multiple sclerosis treatment

Soleimani, M. and Aghayan, H. R. and Goodarzi, P. and Hagh, M. F. and Lajimi, A. A. and Saki, N. and Jahani, F. M. and Javidan, A. N. and Arjmand, B. (2016) Stem cell therapy ‒Approach for multiple sclerosis treatment. Archives of Neuroscience, 3 (1). ISSN 23223944 (ISSN)

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Context: Multiple sclerosis (MS) is an autoimmune and inflammatory disease that affects the central nervous system (CNS). In MS, activated T-cells for self-antigens, such as myelin, attack erroneous targets in the CNS and result in axonal demyelination andneurological disability. Stem cell (SC) therapy has potential applications in treating neurological disorders. Evidence Acquisition: The reasoning for use of SCs from different sources, as a therapeutic option in MS, arose from the expectation that they have the capacity to remyelinate and differentiate into oligodendrocyte precursor cells. Many SC types are under testing for treating MS and, the most common, are neural SC (NSC), embryonic SC (ESC), mesenchymal SC (MSC) and hematopoietic SC (HSC). Results: The NSCs, namely adult NSCs, bone marrow-derived-NSCs and neural progenitor cells, are capable of differentiation into oligodendrocytes and induce remyelination. The MSCs influence on the rate of repair of all endogenous progenitors. The autologous HSC transplantation is an option in cases that do not respond to standard therapy and also meliorate the symptoms and limit progression of disease. The ESCs have shown neuroprotection in cases of MS, through a yet unclear immunosuppression mechanism. Conclusions: Recently, cell transplantation has introduced a novel approach for treatment of neurological disorders, such as MS. Therefore, focusing on safety issues, while bridging from the basic SC sciences to the clinical transplantation trials, has a crucial role in cellular therapy programs. This review will discuss in detail the experimental and clinical use of these SC populations and their probably mechanisms in the treatment of multiple sclerosis. � 2016, Tehran University of Medical Sciences.

Item Type: Article
Keywords: Cell- and Tissue-Based Therapy Hematopoietic Stem Cells Mesenchymal Stromal Cells Multiple Sclerosis Myelin Sheath Stem Cells neurotrophin 3 allogeneic umbilical mesenchymal stem cell bone marrow derived dendritic cell bone marrow derived mesenchymal stem cell cell differentiation cell proliferation cord blood stem cell transplantation embryonic stem cell Expanded Disability Status Scale hematopoietic stem cell hematopoietic stem cell transplantation human immunological tolerance immunomodulation immunosuppressive treatment neural stem cell nonhuman nuclear magnetic resonance imaging oligodendroglia Review stem cell transplantation
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences
Depositing User: مهندس مهدی شریفی
Last Modified: 01 Jun 2018 11:32

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