Repository of Research and Investigative Information

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Ahvaz Jundishapur University of Medical Sciences

THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT

Arzi, A and Hemmati, AA and Ghobishavi, S and Arzi, L (2007) THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT. Jundishapur Journal of Natural Pharmaceutical Products, 2 (1). pp. 18-24. ISSN 2228-7876

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Abstract

Catatonia is one of the major signs of parkinson’s disease which is due to impaired dopamine in extrapyrmidal system. This study was performed to elucidate the role of L-tyrosine, vitamin E and vitamin C on perphenazine-induced catatonia in model of rat. Eight groups of rats were pretreated orally by a single dose of L-tyrosine (1500 mg/kg), vitamin E (250 mg/kg), vitamin C (300 mg/kg), vitamin E plus vitamin C, vitamin E plus L-tyrosine, vitamin C plus L-tyrosine, vitamins E and C plus L-tyrosine and normal saline (control group) for two weeks, respectively. One hour after the last dose, perphenazine (5 mg/kg) was administered (IP) to induce catatonia. Muscular rigidity of animals was determined by scoring method of Morpurgo. The results of this study indicate that L-tyrosine plus vitamins E and C could reduce the perphenazine-induced muscular rigidity better than other groups.

Item Type: Article
Keywords: L-tyrosine, Vitamin E, Vitamin C, Perphenazine, Catatonia, Rat.
Subjects: R Medicine > R Medicine (General)
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 23 Jun 2015 12:16
Last Modified: 10 Feb 2016 06:51
URI: http://eprints.ajums.ac.ir/id/eprint/1683

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