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Ahvaz Jundishapur University of Medical Sciences

ISOLATION OF A NEW MODERATELY HALOPHILIC BROAD-SPECTRUM ANTIBIOTIC PRODUCING ACTINOBACTER

Hamedi, J and Mohammadipanah, F and Amoozegar, MA and Dehghan, S (2007) ISOLATION OF A NEW MODERATELY HALOPHILIC BROAD-SPECTRUM ANTIBIOTIC PRODUCING ACTINOBACTER. Jundishapur Journal of Natural Pharmaceutical Products, 2 (2). pp. 94-104. ISSN 2228-7876

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Abstract

In a screening program for antibiotic producer rare-actinobacteria from soil of Iran, a novel moderately halophilic actinobacter (Q70) was isolated. The strain had the ability of antibiotic production against methicillin resistant Staphylococcus aureus. Maximum antibiotic production was obtained in the medium containing 10% (w/v) NaCl. The strain Q70 had also activity against Enterococcus faecalis, Bacillus subtilis and Pseudomonas aeruginosa. The antibiotic extracted from fermentation broth had low toxicity (681/3 μg/ml LC50) against Artemia salina in brine shrimp lethality test. The antibiotic produced by strain Q70 had polar structure. The strain Q70 is proposed as a new species with the name of Nocardiopsis iraniensis with considering the significant morphological, physiological, molecular and chemotaxonomical differences between Q70 and other species of Nocardiopsis.

Item Type: Article
Keywords: Actinobacteria, Antibiotic, Halophile, MRSA, Nocardiopsis, Pseudomonas aeruginosa.
Subjects: R Medicine > R Medicine (General)
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 23 Jun 2015 21:04
Last Modified: 10 Feb 2016 06:51
URI: http://eprints.ajums.ac.ir/id/eprint/1696

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