Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

Protective effect of Cassia fistula fruit extract on bromobenzene-induced nephrotoxicity in mice

Kalantari, H. and Jalali, M. and Jalali, A. and Salimi, A. and Alhalvachi, F. and Varga, B. and Juhasz, B. and Jakab, A. and Kemeny-Beke, A. and Gesztelyi, R. and Tosaki, A. and Zsuga, J. (2011) Protective effect of Cassia fistula fruit extract on bromobenzene-induced nephrotoxicity in mice. Human and Experimental Toxicology, 30 (10). pp. 1710-1715. ISSN 09603271 (ISSN)

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Abstract

The efficacy of a crude hydro-alcoholic extract of Cassia fistula (golden shower tree) fruit to protect the kidney against bromobenzene-induced toxicity was studied. Negative control mice received normal saline; positive control mice were given 460 mg/kg of bromobenzene; Cassia fistula treated mice received 200, 400, 600 and 800 mg/kg of Cassia fistula fruit extract followed by 460 mg/kg bromobenzene (daily by oral gavage for 10 days). On the 11th day, the mice were sacrificed, blood samples were obtained to assess blood urea nitrogen (BUN) and creatinine levels, and kidneys were removed for histological examination. We found that bromobenzene induced significant nephrotoxicity reflected by an increase in levels of BUN and creatinine that was dose dependently prevented by the Cassia fistula fruit extract. The nephroprotective effect of the Cassia fistula fruit extract was confirmed by the histological examination of the kidneys. To the best of our knowledge, this is the first study to demonstrate the protective effect of Cassia fistula in nephrotoxicity. © SAGE Publications 2011.

Item Type: Article
Keywords: bromobenzene Cassia fistula kidney mouse nephrotoxicity Cassia fistula extract creatinine animal experiment animal model animal tissue article controlled study creatinine blood level drug effect drug efficacy drug megadose histopathology kidney necrosis male nonhuman priority journal renal protection treatment duration treatment response urea nitrogen blood level Animals Blood Urea Nitrogen Bromobenzenes Cassia Fruit Mice Plant Extracts Protective Agents Mus
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences
Depositing User: مهندس مهدی شریفی
Last Modified: 01 Jun 2018 13:13
URI: http://eprints.ajums.ac.ir/id/eprint/18859

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