Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

Protective effects of crocin against cisplatin-induced acute renal failure and oxidative stress in rats

Naghizadeh, B. and Boroushaki, M. T. and Mashhadian, N. V. and Mansouri, S. M. T. (2008) Protective effects of crocin against cisplatin-induced acute renal failure and oxidative stress in rats. Iranian biomedical journal, 12 (2). pp. 93-100. ISSN 1028852X (ISSN)

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Abstract

Background. The major side effect of cisplatin, used in some tumours, is nephrotoxicity. Reactive oxygen species and oxidative damage are the most important factors in cisplatin-induced acute renal failure. The main purpose of this study is to investigate the protective effects of crocin against cisplatin-induced acute renal failure and oxidative stress in rat. Methods. In this study, animals were randomly divided into 5 groups (6 each). Group one received normal saline (2 ml/day, i.p.). Group two received a single dose of cisplatin (5mg/kg, i.p.). Groups 3 to 5 received crocin (100, 200 and 400 mg/kg, i.p., respectively, for 4 consecutive days one hour before a single dose of cisplatin (5 mg/kg) only at the first day. Blood samples were taken out (on the fifth day) for measuring the level of urea and creatinine. The kidneys were removed for histopathological and biochemical examinations. Furthermore, 24-hour urinary factors were measured. Results. Blood urea, creatinine and urinary glucose and protein concentrations in crocin-treated groups were significantly lower than those of cisplatin-treated group in a dose-dependent manner. Histopathological studies showed a massive damage in S3 segment of proximal tubules in cisplatin-treated group. No damage was observed in crocin-treated groups. Crocin treatment resulted in a significant and dose-dependent reduction in malondialdehyde concentration as compared to the cisplatin-treated group. Moreover, crocin produced a significant elevation in total thiol and glutathione peroxidase concentrations, as compared with cisplatin-treated group. Conclusion. The results of the present study suggest that crocin has a protective effect against cisplatin-induced acute renal failure and relative oxidative stress.

Item Type: Article
Keywords: Acute renal failure Cisplatin Crocin Oxidative stress Renal protection creatinine glutathione peroxidase malonaldehyde thiol urea acute kidney failure animal experiment animal model animal tissue article concentration (parameters) controlled study creatinine blood level dose response glucose urine level histopathology kidney injury kidney proximal tubule male nonhuman rat urea blood level Adjuvants, Pharmaceutic Animals Antineoplastic Agents Carotenoids Glycosuria Kidney Failure, Acute Proteinuria Random Allocation Rats Rats, Wistar Animalia Rattus
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences
Depositing User: مهندس مهدی شریفی
Last Modified: 01 Jun 2018 13:13
URI: http://eprints.ajums.ac.ir/id/eprint/19423

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