Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

Role of ATP-sensitive potassium channels in the biphasic effects of morphine on pentylenetetrazole-induced seizure threshold in mice

Shafaroodi, H. and Asadi, S. and Sadeghipour, H. and Ghasemi, M. and Ebrahimi, F. and Tavakoli, S. and Hajrasouliha, A. R. and Dehpour, A. R. (2007) Role of ATP-sensitive potassium channels in the biphasic effects of morphine on pentylenetetrazole-induced seizure threshold in mice. Epilepsy Research, 75 (1). pp. 63-69. ISSN 09201211 (ISSN)

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Abstract

Although several studies have indicated that the opioid receptor agonist morphine exerts biphasic effects on clonic seizure threshold, as yet little is known of the underlying mechanisms in this effect. In the present study, using the specific ATP-sensitive K+ (KATP) channel blocker glibenclamide and the specific KATP channel opener cromakalim, the possible involvement of KATP channels in the effects of morphine on pentylenetetrazole (PTZ)-induced seizure threshold in mice was investigated. Acute administration of lower doses of morphine (1, 3 and 7.5 mg/kg, i.p.) increased and higher doses of morphine (30 and 60 mg/kg, i.p.) decreased the PTZ-induced seizure threshold. Glibenclamide (2.5-5 mg/kg) increased the PTZ-induced seizure threshold. Non-effective dose of cromakalim (0.1 μg/kg) inhibited anticonvulsant effect of glibenclamide (5 mg/kg). Acute administration of non-effective dose of glibenclamide (1 mg/kg) interestingly inhibited both anticonvulsant and proconvulsant effects of morphine and this effect was significantly reversed by cromakalim (0.1 μg/kg). These results support the involvement of KATP channels in the modulation of seizure threshold by morphine. © 2007 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: ATP-sensitive potassium channel Clonic seizure threshold Mice Morphine Pentylentetrazole adenosine triphosphate sensitive potassium channel cromakalim dimethyl sulfoxide glibenclamide glucose morphine sulfate pentetrazole animal experiment animal model article clonic seizure controlled study dose response drug antagonism drug dose increase drug effect glucose blood level mouse nonhuman priority journal seizure seizure threshold single drug dose Adenosine Triphosphate Animals Behavior, Animal Blood Glucose Disease Models, Animal Dose-Response Relationship, Drug Drug Interactions Glyburide Hypoglycemic Agents Male Narcotics Pentylenetetrazole Potassium Channels Seizures Severity of Illness Index
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences
Depositing User: مهندس مهدی شریفی
Last Modified: 01 Jun 2018 13:14
URI: http://eprints.ajums.ac.ir/id/eprint/19537

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