Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

Relationship of serum adiponectin with blood lipids, HbA1c, and hs-CRP in type II diabetic postmenopausal women

Goodarzi, M. T. and Babaahmadi-Rezaei, H. and Kadkhodaei-Eliaderani, M. and Haddadinezhad, S. (2007) Relationship of serum adiponectin with blood lipids, HbA1c, and hs-CRP in type II diabetic postmenopausal women. Journal of Clinical Laboratory Analysis, 21 (3). pp. 197-200. ISSN 08878013 (ISSN)

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Abstract

Adipose tissue has been considered an important endocrine organ. Adiponectin secretes from adipose tissue and plays an important role in the regulation of glycemia, β-oxidation in muscle, and decreased insulin resistance in the liver. The objectives of this study were to compare the levels of adiponectin, hs-C-reactive protein (CRP), HbA1c, and blood lipids among diabetic and healthy postmenopausal women, and to determine the relationship between circulating adiponectin and development of type II diabetes. This case-control study was performed on 28 diabetic and 42 age-matched healthy women. All participants were postmenopausal. Serum adiponectin concentrations, serum triglycerides (TG), cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) concentrations were determined. Blood HbA1c and serum hs-CRP were also measured. Adiponectin levels were significantly decreased (P < 0.01) in the diabetic patients as compared to normal control subjects. Adiponectin levels were negatively associated with hs-CRP, LDL-C, HbA1c, TG, and total cholesterol (TC). A positive correlation was observed between adiponectin and HDL-C. The obtained data indicate that diabetic women have lower adiponectin levels compared to healthy women. HbA1c as an indicator of glycemic control has a negative correlation with serum adiponectin. Adiponectin may play an important role in the pathogenesis of diabetes, and may be an independent predictor of the development of diabetes in women. © 2007 Wiley-Liss, Inc.

Item Type: Article
Keywords: Adiponectin Glycated hemoglobin hs-CRP C reactive protein cholesterol hemoglobin A1c high density lipoprotein cholesterol lipid low density lipoprotein cholesterol triacylglycerol adipose tissue adult article case control study cholesterol blood level clinical article comparative study controlled study correlation analysis disease association fatty acid oxidation female glucose blood level hemoglobin determination human insulin resistance lipid blood level non insulin dependent diabetes mellitus pathogenesis postmenopause triacylglycerol blood level Biological Markers C-Reactive Protein Diabetes Mellitus, Type 2 Hemoglobins Humans Lipids Middle Aged Predictive Value of Tests
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences
Depositing User: مهندس مهدی شریفی
Last Modified: 01 Jun 2018 13:14
URI: http://eprints.ajums.ac.ir/id/eprint/19538

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