Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

Comparison of the Effects of Juglans nigra Green Husk and Clotrimazole on Candida albicans in Rats

Abedi, Parvin and Yaralizadeh, Masumeh and Fatahinia, Mahnaz and Namjoyan, Foroogh and Nezamivand-Chegini, Salimeh and Yaralizadeh, Maryam (2018) Comparison of the Effects of Juglans nigra Green Husk and Clotrimazole on Candida albicans in Rats. Jundishapur Journal of Microbiology, 11 (2). ISSN 2008-3645

Full text not available from this repository.
Official URL: https://doi.org/10.5812/jjm.58151

Abstract

Background: Black walnut (Juglans nigra) is known to have antimicrobial and antifungal effects in vitro. Objectives: This study aimed to compare the effects of extracts derived from green-husked walnut with clotrimazole against Candida albicans in female rats. Methods: In this study, 35 female Wistar rats were randomly assigned to 5 groups. A total of 4 groups of rats were infected vaginally with C. albicans and 1 group was not infected (negative control). The 4 infected groups received the following treatments: 2 groups received vaginal creams containing 2% or 4% of J. nigra extracts, respectively, 1 group received 1% clotrimazole, and 1 group did not receive any treatment (positive control). All rats received treatments for 2 weeks. Results: The mean number of colony forming unit (CFUs) before intervention was 308.2 � 8.73 and 219 � 13.4 in the 2% and 4% J. nigra group, 312.7 � 28.32 in the clotrimazole group, 233.85 � 8.15 in the positive control, and 0 in the negative control group (P < 0.001). After 1 week, the number of CFUs significantly decreased to 71.1�3.9 in the 2% J. nigra, 0 in both 4% J. nigra and clotrimazole groups, 230.7�9.86 in the positive control, and 0 in the negative control group (P < 0.001). After 2 weeks, no CFUs were detected in any of the infected groups except for the positive control group. Conclusions: Vaginal creams containing 4% J. nigra significantly eliminated C. albicans in female rats after 1 week and its effect was similar to that of clotrimazole.

Item Type: Article
Keywords: Keywords: Clotrimazole, Vaginal Cream, Candida albicans, Juglans nigra
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 10 Nov 2018 09:33
Last Modified: 10 Nov 2018 09:33
URI: http://eprints.ajums.ac.ir/id/eprint/20517

Actions (login required)

View Item View Item