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Ahvaz Jundishapur University of Medical Sciences

Evaluation of the Antimicrobial Effect of Chitosan/Polyvinyl Alcohol Electrospun Nanofibers Containing Mafenide Acetate

Abbaspour, Mohammadreza and Sharif Makhmalzadeh, Behzad and Rezaee, Behjat and Shoja, Saeed and Ahangari, Zohreh (2015) Evaluation of the Antimicrobial Effect of Chitosan/Polyvinyl Alcohol Electrospun Nanofibers Containing Mafenide Acetate. Jundishapur Journal of Microbiology, 8 (10). ISSN 2008-3645

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Official URL: http://doi.org/10.5812/jjm.24239

Abstract

Background:Chitosan, an important biodegradable and biocompatible polymer, has demonstrated wound-healing and antimicrobial properties. Objectives: This study aimed to evaluate the antimicrobial properties of mafenide acetate-loaded nanofibrous films, prepared by the electrospinning technique, using chitosan and polyvinyl alcohol (PVA). Materials and Methods: A 32 full factorial design was used for formulating electrospinning solutions. The chitosan percentage in chitosan/PVA solutions (0%, 10%, and 30%) and the drug content (0%, 20%, and 40%) were chosen as independent variables. The release rate of mafenide acetate from nanofibrous films and their microbial penetration were evaluated. The antimicrobial activity of different nanofibrous film formulations against Staphylococcus aureus and Pseudomonas aeruginosa was studied. Results: The results indicated that all nanofibrous films, with and without drug, can prevent bacterial penetration. Incorporation of mafenide acetate into chitosan/PVA nanofibers enhanced their antimicrobial activity against P. aeruginosa and S. aureus. Conclusions: Overall, the results showed that chitosan/polyvinyl alcohol (PVA) nanofibrous films are applicable for use as a wound dressing with protective, healing, and antimicrobial effects.

Item Type: Article
Keywords: Burns; Nanofibers; Chitosan; Polyvinyl Alcohol; Mafenide
Subjects: R Medicine > R Medicine (General)
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 20 Jan 2016 10:39
Last Modified: 20 Jan 2016 10:39
URI: http://eprints.ajums.ac.ir/id/eprint/2094

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