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Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

Plasma Levels of IFN-γ, IL-4, IL-6 and IL-17 in HIV-Positive Patients With Oral Candidiasis

Ayatollahi Mousavi, Seyyed Amin and Asadikaram, Gholamreza and Nakhaee, Nouzar and Izadi, Alireza (2016) Plasma Levels of IFN-γ, IL-4, IL-6 and IL-17 in HIV-Positive Patients With Oral Candidiasis. Jundishapur Journal of Microbiology, Inpres (Inpres). ISSN 2008-3645

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Official URL: http://doi.org/10.5812/jjm.32021

Abstract

Background: Cell-mediated immunity (CMI) by CD4+ Th-type (T helper-type) cells is the predominant host defense mechanism against oral candidiasis (OC) in HIV-infected individuals. Weakened CMI and depletion of CD4+ T cells are the main factor contributing to the output of OC in HIV-positive individuals. The cytokines produced by Th1, Th2 and Th17 cells play a role in mediating an increased susceptibility to OC during HIV infection. Objectives: The present study investigated the plasma concentration of IFN-γ, IL-4, IL-6 and IL-17 in HIV-1 patients suffering from OC. Patients and Methods: In total, 98 samples in four groups (HIV-positive and HIV-negative persons, with and without OC) were obtained from the oral cavities of participants and cultured on Sabouraud’s dextrose agar and CHROMagar. Also, blood samples were obtained to assess plasma levels of IFN-γ, IL-4, IL-6 and IL-17, using the ELISA technique. Results: There was a statistically significant difference in the plasma concentration of IFN-γ, IL-6 and IL-17 but not of IL-4. Our findings suggest a significant interaction between fungal infection and HIV on expression of assessed cytokines. Conclusions: Fungal infection and HIV, alone and together, can seriously alter immune system function as assessed by measuring the levels of plasma cytokines. Therefore, these results provide important new information relative to the putative immune-based factors associated with resistance and/or susceptibility to OC in HIV-positive persons.

Item Type: Article
Keywords: Oral Candidiasis, HIV, IL-4, IL-6, IL-17, IFN-Gamma
Subjects: R Medicine > R Medicine (General)
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 06 Nov 2016 05:47
Last Modified: 06 Nov 2016 05:47
URI: http://eprints.ajums.ac.ir/id/eprint/2524

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