Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ahvaz Jundishapur University of Medical Sciences

Herpes Simplex Virus Meningitis in Children in South East of Caspian Sea, Iran

Tabarraei, Alijan and Azadfar, Somayeh and Cheraghali, Fatemeh and Moradi, Abdolvahab and Javid, Naeme (2014) Herpes Simplex Virus Meningitis in Children in South East of Caspian Sea, Iran. Jundishapur Journal of Microbiology, 7 (1). pp. 1-4. ISSN 2008-4161

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Background: Herpes simplex virus (HSV) is a member of Herpesviridae and a leading cause of human viral diseases. Meningitis occurs as a complication of HSV-1 or HSV-2 primary infection. Objectives: We aimed to evaluate HSV meningitis in children in Gorgan province, Iran. Patients and Methods: Forty-five cerebrospinal fluid samples were taken from children referred with meningitis symptoms. Samples with negative bacterial culture results were tested for viral, biochemical and cytological assays. DNA extraction and PCR were performed. Results: HSV-1 detected in 4 (8.8%) samples without any HSV-2 infections. Cases with positive results had fever and CSF pleocytosis. Vomiting, headache and higher count of WBC were observed in 3, 2 and 3 cases respectively. The cerebrospinal fluid (CSF) glucose and protein levels were normal and 3 cases showed positive C-reactive protein (CRP) results. Also erythrocyte sedimentation rate (ESR) was higher than normal in all positive cases. Conclusions: Distribution of HSV types in children with meningitis in our area predominantly was type 1 compared with type 2, which has been reported more in other area.

Item Type: Article
Keywords: Herpes Simplex Virus; Meningitis; CSF; PCR; Children
Subjects: Q Science > Q Science (General)
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 01 Jun 2015 08:44
Last Modified: 10 Feb 2016 06:16

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