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Ahvaz Jundishapur University of Medical Sciences

Intensity of HLA-A2 Expression Significantly Decreased in Occult Hepatitis B Infection

Kazemi Arababadi, Mohammad and Askari, Azam and Hassanshahi, Gholam Hossein and Ghalebi, Seyed Razi and Jafarzadeh, Abdollah and Mohit, Maryam and Hajghani, Masomeh (2014) Intensity of HLA-A2 Expression Significantly Decreased in Occult Hepatitis B Infection. Jundishapur Journal of Microbiology, 7 (6). pp. 1-4. ISSN 2008-4161

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Abstract

Background: Occult hepatitis B infected (OBI) patients cannot eradicate hepatitis B virus (HBV)-DNA from their liver and peripheral blood, completely. Objectives: The main aim of this study was to investigate the rate of HLA-A2 expression on peripheral blood mononuclear cells (PBMCs) of patients with OBI. Materials and Methods: In this experimental study, intensity of HLA-A2 was measured on the PBMCs of 57 OBI patients and 100 HBsAg-/anti-HBc+/HBV-DNA samples were enrolled as controls; measurements were performed using the flow cytometry technique. Results: Flow cytometric analysis indicated that 19 (33.3%) OBI patients and 28 (28%) controls expressed HLA-A2 antigen on their PBMCs. There was no significant difference between the two groups regarding the rate of individuals expressing HLA-A2 antigen. Statistical analyses showed that the intensity of HLA-A2 expression significantly decreased in OBI patients (3.58 ± 0.1) in comparison to healthy controls (4.21 ± 0.25; P < 0.001). Conclusions: According to these results it can be concluded that decreased intensity of HLA-A2 on the PBMCs of OBI patients may lead to resistance of HBV in the patients.

Item Type: Article
Keywords: Occult; Hepatitis B; Infection; HLA-A2; DNA
Subjects: R Medicine > R Medicine (General)
Depositing User: آقای بهرام سوسنی غریب وند
Date Deposited: 01 Jun 2015 08:57
Last Modified: 10 Feb 2016 06:29
URI: http://eprints.ajums.ac.ir/id/eprint/544

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